Myositis Antibodies Profile Test in Ahmedabad, Gujarat | Myositis Autoantibodies Panel
Myositis is a disease of muscle where there is a problem with walking/standing properly due to inflammatory disorder of the muscles.
Qline Advanced Diagnostic Laboratory offer a Myositis Antibody Panel to help in the diagnosis of the idiopathic inflammatory myopathies, commonly referred to as myositis. When combined with clinical features, the myositis-specific autoantibodies can aid clinicians in making a diagnosis of myositis, polymyositis, dermatomyositis, anti-synthetase syndrome and related conditions. The Myositis Antibody Panel provides a quantitative in vitro assay for human antibodies present in serum and plasma of the IgG class to 16 different antigens.
Autoimmune Inflammatory Myopathies 16 Antigens : ( Mi-2 alpha, Mi-2 beta, TIF1g, MDA5, NXP2, SAE1, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ, Ro-52 Separately) – IgG antibodies detected separately by immunoblot method.
- Result comes in 1-2 Days
- Total Cost : Rs 9000
- Time required in Lab : 10 minutes for blood collection
- No special preparation required for the patient.
- Report available whatsapp / email / courier
Antibodies to the sixteen common antigens are determined by an immunoblot profile assay. The color developed for each antigen is determined by densitometry and the intensity of the color is proportional to the antibody reactivity. The results are given in arbitrary intensity units
| Antibody | Disease association |
| Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG | Polymyositis with associated interstitial lung disease, SLE, Systemic Sclerosis |
| Mi-2 (nuclear helicase protein) Antibody | Dermatomyositis |
| PL-7 (threonyl-tRNA synthetase) Antibody | Myositis (PM, DM) with associated interstitial lung disease, SLE, Systemic Sclerosis |
| PL-12 (alanyl-tRNA synthetase) Antibody | Myositis (PM, DM) |
| EJ (glycyl-tRNA synthetase) Antibody | Polymyositis |
| SRP (Signal Recognition Particle) Ab | Polymyositis & dermatomyositis |
| OJ (isoleucyl-tRNA synthetase) Antibody | Polymyositis |
| SAE1 (SUMO activating enzyme) Ab | DM & DM asso. Interstitial Lung Disease |
| MDA5 (CADM-140) Ab | Dermatomyositis |
| NXP2 (Nuclear matrix protein-2) Ab | Juvenile Myositis (PM/DM) |
| TIF-1 gamma (transcriptional intermediary factor 155 kDa) Ab | Dermatomyositis, Cancer associated Myositis |
| Anti-Ku Ab | Autoimmune Myositis |
| PM scl -100/75 (anti-exosome) Ab | PolyMyositis, Dermatomyositis & Systemic sclerosis |
| SSA/RO-52 (Anti-Sjögren’s-syndrome-related antigen A) ab | Myositis (PM, DM), other rheumatic diseases |
| SAE-2 (SUMO activating enzyme) Ab | Autoimmune Myositis |
myositis antibody profile
TEST INTERPRETATION
Results
Positive: as a single test, not diagnostic for inflammatory myopathy
Negative: does not rule out inflammatory myopathy
Limitations
Results by themselves are not diagnostic; strong clinical correlation is recommended
Negative results do not rule out a diagnosis of inflammatory myopathy or overlap syndrome
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